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SpamBayes is also a pretty language-neutral application. Really, those are the applications that matter most -- the best evidence of Python's quality will be the software we right using it, not the libraries we develop or the ideas we come up with.
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I'd argue that mailman has also transcended issues of it being developed in Python. It's just the best mailing list manager out there.
Sadly, Roundup won't make it onto that list any time soon. I'm still down around a few hundred downloads per month (I think I once broke the 700 mark - I've only had 11,000 downloads over the 3 years the project's been alive ;)
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Actually, BitTorrent is what attracted me to Python.
I saw that it could do GUI stuff (wxPython) quite nicely, and could be distributed easily enough (py2exe).
It was refreshing to see a non-Java P2P app.